Phorbol Esters Induce Differentiation of Human
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منابع مشابه
Induction of terminal differentiation in human promyelocytic leukemia cells by tumor-promoting agents.
Human promyelocytic leukemia cells (HL-60) were induced to differentiate into mature cells by the tumor-promoting agent phorbol-12-myristate-13-acetate and other related phorbol diesters. Differentiation was determined by an increase in the percent of myelocytes, metamyelocytes, and other mature myeloid cells as well as by an increase in the percent of phagocytizing cells. Induction of differen...
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Tumor-promoting phorbol esters including 12-O-tetradecanoylphorbol-13-acetate (TPA), specific inhibitors for erythroid differentiation in mouse Friend cells, induce a newly identified nuclear protein with a molecular weight of 54,000 (p54) in Friend cells. Phorbol, an analogue of TPA with neither tumor-promoting nor differentiation-inhibitory activity, did not induce p54. In a variant cell line...
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Phorbol esters induce the human HL-60 promyelocytic cell line to differentiate along a monocytic pathway. This induction of differentiation may involve phorbol esterinduced activation of the phospholipidand calcium-dependent protein kinase C. Bryostatin 1 #{149} a macrocyclic lactone. has been shown to compete with phorbol esters for binding to protein kinase C. We have confirmed that bryostati...
متن کاملInduction of a Novel Nuclear Protein (p54) by Phorbol Esters in Mouse Erythroleukemia (Friend) Cells1
Tumor-promoting phorbol esters including 12-O-tetradecanoylphorbol-13-acetate (TPA), specific inhibitors for erythroid differentiation in mouse Friend cells, induce a newly identified nuclear protein with a molecular weight of 54,000 (p54) in Friend cells. Phorbol, an analogue of TPA with neither tumor-promoting nor differentiation-inhibitory activity, did not induce p54. In a variant cell line...
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As described in this review, both partially purified and recombinant interferons are potent modulators of differentiation in diverse cell culture systems (Table 2). Depending on the target cell, interferon exerts either an inhibitory or an inductive effect on cell differentiation. In certain myeloid leukemic cells, such as HL-60, interferon by itself is growth suppressive but does not induce ce...
متن کاملPhorbol esters induce changes in adenosine deaminase, purine nucleoside phosphorylase, and terminal deoxynucleotidyl transferase messenger RNA levels in human leukemic cell lines.
We have studied the expression of mRNA encoding adenosine deaminase (ADA; EC 3.5.4.4), purine nucleoside phosphorylase (PNP; EC 2.4.2.1), and terminal deoxynucleotidyltransferase (TdT; EC 2.7.7.31) in different leukemic cell lines of B- and T-cell lineage. Incubation of leukemic cells in the presence of the phorbol esters, 12-O-tetradecanoyl-phorbol-13-acetate or phorbol 12,13-dibutyrate, resul...
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